21-Day Detox
21-Day Detox ingredients
How to take 21-Day Detox
21-Day Detox key facts
21-Day Detox lifestyle
21-Day Detox supplement facts label
21-Day Detox customer photo

21-Day Detox

3 Phases: Colon, Liver, Nutrition
What's inside
  • Liver-DLiver-D×1
  • Proenzi+Proenzi+×1
  • Colon-DColon-D×4
One-time purchase
Quantity
1
Total $189.94
Secure checkout · 30-day guarantee · Free returns
30-Day Guarantee
47K+ Customers
24hr Shipping
21-Day Detox $189.94
Fast Shipping Delivered between Thursday, October 29 and Sunday, November 1
100% Money-Back Guarantee Satisfaction guaranteed or we'll refund 100% of your money.
21-Day Detox - Complete 3-Phase Colon, Liver and Nutrition Reset
Complete 3-Phase Detox System

21 Days to a Cleaner, Lighter You.

The 21-Day Detox is a three-phase kit: a 5-day colon cleanse with COLON-D and PROENZI+, a 2-day liver flush with Liver-D, and a 14-day guided eating plan with no sugar or refined carbohydrates. Four COLON-D bags, one Liver-D (Liver Support + Liver Mix) and 60 PROENZI+ capsules: everything you need for the full 21 days, with a day-by-day guide.

Phase 1 · Colon CleanseDays 1–5: 1 cup of COLON-D + 1 PROENZI+ capsule before each meal
Phase 2 · Liver FlushDays 6–7: Liver Support in apple juice, then Liver Mix with lemon
Phase 3 · Eating PlanDays 8–21: guided menus with COLON-D + PROENZI+ before meals
4 COLON-D Bags · 1 Liver-D · 60 PROENZI+ Capsules Natural Formulas · Day-by-Day Guide
21-Day Detox on a kitchen counter
21
Days, One Kit
3
Phases: Colon, Liver, Nutrition
21-Day Detox supplement facts label

Reset your body from the inside out with the 21-Day Detox.

Natural Colon Cleanse
Supports Liver Function & Bile Flow
Replenishes Gut Flora With Probiotics
Supports Digestion & Nutrient Absorption
Relieves Occasional Bloating & Gas
Supports Immune Defenses & Metabolism
No Other Detox Compares

Why the 21-Day Detox is Your Best Choice

Most detox programs are a box of tea bags and a promise. Here is how the 21-Day Detox compares to typical detox programs.

Comparing the 21-Day Detox
To The Competition
21-Day Detox 21-Day Detox
Typical Detox
Programs
Complete 3-Phase System: Colon, Liver and Eating Plan
Colon Cleanse With a 100% Botanical Infusion (Five Leaves, No Senna)
Two-Step Liver Flush: Liver Support + Liver Mix
Probiotics and Digestive Enzymes Included (PROENZI+, 60 Capsules)
Day-by-Day Protocol With Exact Times
14-Day Eating Plan With Daily Menus and an Allowed-Foods List
Supports Regular Bowel Movements
All 21 Days in One Kit: 4 COLON-D Bags, Liver-D, 60 PROENZI+

Three products, one sequence: colon first, then liver, then the plate

Phase 1 starts with COLON-D, a 100% botanical infusion of persimmon, mallow, marshmallow, holy thistle and blessed thistle leaves. The mucilage-rich leaves soothe the intestinal lining and give a mild laxative effect, while the thistles support liver function. Every cup goes with a PROENZI+ capsule: three Lactobacillus strains (acidophilus, casei and plantarum at 48 billion CFU/g each), Aspergillus protease and five digestive enzymes (bromelain, papain, lipase, lactase and alpha galactosidase at 24,000 U/g each) that break down what you eat and help replenish your gut flora.

Phase 2 is the Liver-D flush, two bottles made to work together. Liver Support is a powder that delivers, per serving (4 per bottle), 2,940 mg of vitamin C and a 9.31 g blend of magnesium sulfate, yucca root, artichoke, dandelion, milk thistle, ginger and turmeric root extract with 95% curcuminoids; the whole bottle is mixed in apple juice and taken in four doses. Liver Mix is 118 ml of extra virgin olive oil with vitamin E (100% DV), shaken with fresh lemon juice and taken all at once at 10:00 pm. Phase 3 puts the cleanse to work: 14 days of a guided eating plan with no sugar or refined carbohydrates, still with COLON-D and PROENZI+ before each meal.

The real ingredients of the 21-Day Detox on white marble: persimmon, mallow, marshmallow and thistle leaves, Epsom salt, vitamin C powder, yucca root, artichoke, dandelion, milk thistle, ginger, turmeric, olive oil and open probiotic capsules
21-Day Detox as part of a daily routine

Your liver performs over 500 functions every day

Your liver filters your blood, produces bile, stores nutrients and processes what you eat, drink and breathe, around the clock. Your colon finishes the job, moving waste along and absorbing the last water and minerals. When either one slows down under processed food, alcohol, medication or stress, you feel it as heaviness, bloating, gas and low energy. The 21-Day Detox works in that order: it clears the colon first, so the liver flush on days 6 and 7 has a clear path, and then feeds both with 14 days of real food.

It is a periodic reset, not a daily supplement. The guide sets the exact times of every dose, and the eating plan gives you daily menus with three meals and two snacks and an allowed-foods list so you know what to put on the plate for the two weeks that make the results last.

How to do the 21-Day Detox

1
Prep (Sunday night)
Boil 1 liter (a quart) of water, turn off the heat and add the whole contents of one COLON-D bag. Let it steep overnight. In the morning add 3 liters (3 quarts) of room-temperature water: one gallon of tea. Keep it refrigerated. Never microwave it and never add sugar or sweeteners.
2
Days 1–5 · Colon cleanse
Drink 1 cup (250 ml / 8 oz) of COLON-D and take 1 PROENZI+ capsule 20 minutes before breakfast, lunch and dinner. The tea can be hot or cold.
3
Day 6 · Liver Support
Stop the tea for these two days. Light breakfast; 1 PROENZI+ before a lunch of chicken broth with vegetables. At 3:00 pm mix the whole Liver Support bottle in 24 oz (710 ml) of organic apple juice (purified water if you are diabetic) and refrigerate for 3 hours. Drink 6 oz (178 ml) at 6:00 pm and 6 oz at 8:00 pm. No dinner: an apple, 10 almonds or cucumber if you are hungry.
4
Day 6 · Liver Mix at 10:00 pm
At 9:50 pm squeeze 4 oz (120 ml) of fresh lemon juice. At 10:00 pm pour it into the Liver Mix bottle, close it, shake hard until blended and drink it all right away. Lie down immediately on your right side and stay in that position to sleep.
5
Day 7 · Finish the flush
On waking (7–8 am) drink 6 oz (178 ml) of the Liver Support mix with 1 PROENZI+. At 10:00 am drink the last 6 oz. Skip breakfast; light lunch and dinner (chicken broth with vegetables) with 1 PROENZI+ before each. Stay well hydrated.
6
Days 8–21 · Eating plan
Back to 1 cup of COLON-D + 1 PROENZI+ before breakfast, lunch and dinner, and follow the eating guide: no sugar or refined carbohydrates, whole foods, protein, vegetables and healthy fats.

Formulated by Pharmaceutical Scientists and
Verified by our Clinical Advisory Board

Armando González Mora

Armando González Mora, PCB

Pharmaceutical Chemist Biologist & Formulation Specialist

Graduate of BUAP with 8+ years specializing in nutraceutical R&D. Creator of 150+ innovative formulas, expert in liposomal technology and nanotechnology for enhanced bioavailability. Led COFEPRIS Good Manufacturing Practices certification.

Luis Alonso Rodríguez Suárez

Luis Alonso Rodríguez Suárez, PCB

Pharmaceutical Chemist Biologist & Quality Control Expert

BUAP graduate with 12+ years in pharmaceutical and nutraceutical industries. Expert in GMP implementation and NOM-059 certification. Specializes in process validation, quality systems, and critical utilities management.

Sharon Gutiérrez Falcón

Sharon Gutiérrez Falcón, PCB

Pharmaceutical Chemist Biologist & Health Regulation Specialist

BUAP graduate recognized for research excellence at international conferences. Selected by CONACYT for genetic research projects. Experience at Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.

Wendolyne Meraz Lizcano

Wendolyne Meraz Lizcano

Licensed Nutritionist & Clinical Nutrition Specialist

Licensed in Nutrition with a postgraduate degree in Clinical Nutrition and Ketogenic Diet certification. Specialist in metabolic approach to health and wellness.

Dr. Julio César Uribe

Dr. Julio César Uribe

Clinical Biochemical Nutrition Specialist

Clinical Biochemical Nutrition specialist from Tec de Monterrey. Advanced studies from Yale and Anáhuac, focused on metabolic syndrome, fertility, hormonal health, and sports nutrition.

Got Questions?

Frequently Asked Questions

Everything you need to know about the 21-Day Detox

What is the 21-Day Detox?

The 21-Day Detox (21D Challenge / Reto 21D) is a three-phase program that combines three iEvolution products with a guided eating plan:

  • Phase 1, days 1–5: colon cleanse with the COLON-D infusion and PROENZI+ probiotics and enzymes before each meal.
  • Phase 2, days 6–7: liver flush with Liver-D, two bottles (Liver Support and Liver Mix) taken in a precise sequence over a weekend.
  • Phase 3, days 8–21: a 14-day eating plan with no sugar or refined carbohydrates, keeping COLON-D and PROENZI+ before meals.

It is designed to start on a Monday, so the liver flush falls on Saturday and Sunday.

What comes in the kit?

One kit covers the full 21 days:

  • 4 bags of COLON-D (0.2 oz / 8 g each): each bag brews one gallon (4 liters) of infusion. 2 calories per serving, no caffeine, no sugar.
  • 1 Liver-D, made up of two bottles: Liver Support (48 g powder, 4 servings of 12.25 g) and Liver Mix (4 fl oz / 118 ml).
  • 1 bottle of PROENZI+: 60 capsules of 480 mg with probiotics, prebiotics and digestive enzymes.
  • The step-by-step instructions (PDF) and access to the eating guide for days 8–21.
What are the ingredients of each product?

COLON-D (per bag): persimmon leaves, mallow leaves, holy thistle, marshmallow leaves and blessed thistle. Other ingredients: silicon dioxide. 2 calories, 0 g fat, 0 g sugar.

Liver Support (per 12.25 g serving, 4 per bottle): vitamin C (ascorbic acid) 2,940 mg and 9.31 g of the iEvo liver detox blend: magnesium sulfate USP, yucca root, artichoke 4:1 extract, dandelion 4:1 extract, milk thistle extract, ginger root and turmeric root extract with 95% curcuminoids.

Liver Mix (1 bottle, 118 ml): extra virgin olive oil 118 ml and vitamin E 25.35 IU (100% DV).

PROENZI+ (per 480 mg capsule): Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus plantarum and Aspergillus fungal protease at 48 billion CFU/g each; bromelain, papain, fungal lipase, fungal lactase and alpha galactosidase at 24,000 U/g each. Gluten-free, Non-GMO, no additives.

How does the liver flush on days 6 and 7 work?

Liver-D is two bottles that work as a pair. Liver Support is a powder you mix in 24 oz (710 ml) of organic apple juice at 3:00 pm on day 6 and drink in four 6 oz (178 ml) doses: 6:00 pm, 8:00 pm, on waking on day 7 and 10:00 am. Its magnesium sulfate and vitamin C prepare the digestive tract, and the artichoke, dandelion, milk thistle, ginger and turmeric support liver function and bile flow.

Liver Mix is 118 ml of extra virgin olive oil with vitamin E. At 10:00 pm on day 6 you shake it with 4 oz (120 ml) of fresh lemon juice, drink it all at once and lie on your right side to sleep. During these two days you stop the COLON-D tea, eat light (chicken broth with vegetables) and skip dinner on day 6 and breakfast on day 7. Bowel movements may increase after the evening doses: plan to stay home.

Is the 21-Day Detox safe? Who should not do it?

All three products are made with natural ingredients, and the program is a periodic cleanse, not for continuous daily use. It is for adults only: iEvolution does not recommend it for anyone under 18 or under 100 lb (50 kg) of body weight.

Do not do the cleanse if you are pregnant or nursing, or if you have active gallstones, a bile duct obstruction or a severe liver disease such as active hepatitis or cirrhosis: the artichoke, dandelion and milk thistle in Liver Support and the olive oil in Liver Mix stimulate bile flow, and Liver Support contains magnesium sulfate, which already has a marked laxative effect. Do not combine it with other laxatives, cleansers or digestive supplements, and do not exceed the stated doses.

Talk to your doctor first if you take any medication, especially anticoagulants such as warfarin (turmeric and vitamin E can add to their effect) or drugs processed by the liver; if you have diabetes or high blood glucose (mix Liver Support in purified water instead of apple juice and follow your doctor’s dietary guidance); or if you have high blood pressure, a heart or thyroid condition, or any digestive condition. Bromelain comes from pineapple and papain from papaya: if you are allergic to either fruit, ask your physician before taking PROENZI+. COLON-D has no caffeine. Increased bowel movements are expected during the flush; stay well hydrated the whole time. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Can I eat normally during the challenge?

Days 1–5: eat normally, but go easy on processed food and heavy carbohydrates, and take your tea and PROENZI+ 20 minutes before each meal.

Days 6–7: follow the specific meal guidance: light breakfast on day 6 (scrambled eggs, a little fruit), chicken broth with vegetables and some shredded chicken for lunch, no dinner. On day 7 skip breakfast and keep lunch and dinner light. Avoid bread, rice, tortillas and sugar.

Days 8–21: follow the eating guide. It removes sugar and refined carbohydrates and replaces them with protein, vegetables and healthy fats, with daily menus of three meals and two snacks and an allowed-foods list. You eat when you are hungry; you do not have to finish every menu.

What can I expect, and how often can I repeat it?

Results vary from person to person. The products are formulated to support regular bowel movements, a lighter digestion, relief from occasional gas and bloating, and normal energy levels. The two weeks of Phase 3 are what make the change last: they turn the cleanse into habits.

The 21-Day Detox is a periodic reset, not a daily supplement. iEvolution recommends repeating the full program every 3 to 4 months. Between challenges you can keep taking PROENZI+ daily for digestive support and use COLON-D occasionally.

What is the difference between the 21-Day Detox and the 7-Day Detox?

The 7-Day Detox covers only phases 1 and 2: the colon cleanse and the liver flush, the first seven days of this program. It includes Liver-D, one COLON-D bag and 15 PROENZI+ capsules.

The 21-Day Detox adds the 14-day eating plan and the supplies to go with it: four COLON-D bags and 60 PROENZI+ capsules, so you keep the tea and the capsules before every meal through day 21. If you want a quick weekend reset, choose the 7-Day. If you want to change how you eat afterward, choose the 21-Day.

4.7
161 reviews
5 stars
119
4 stars
42
3 stars
0
2 stars
0
1 stars
0

Share Your Experience

Help others by sharing your thoughts on this product

Click or drag files here to upload

Up to 5 images • Videos up to 50MB

Customer Reviews (161)

V

Vanessa Robinson

4 weeks ago
Verified

Complete and thorough

The most complete detox program I've tried. Three phases addressing colon, liver and gut health, plus a nutrition guide. Lost 11 lbs and feel better than I have in years. Completley recommend 🌟.
F

Freddy Williams

1 month ago
Verified

Este es el programa que funciona

Despues de probar muchas cosas este fue el programa que finalmente funciono. 21 dias completos con resultados de 12 libras perdidas y una salud completley renovada. Los ingredientes son de primera 💚.
D

Denise Cruz

1 month ago
Verified

Very happy with results

21 days well spent. Lost 10 lbs, digestion improved dramatically, energy levels up. The phased approach means each part of the program builds on the last. Excellent health investment.
A

Armando Perez

1 month ago
Verified

El reset que necesitaba

Mi medico me dijo que necesitaba limpiar mi higado y mejorar mi digestion. Este programa de 21 dias lo hizo todo. Mi doctor quedo impresionado con los resultados de mis labs despues del programa 🔥.
T

Tamara Anderson

1 month ago
Verified

Glowing reviews because it works

I was skeptical of the glowing reviews for this program. Now I understand them because they're all true. Lost 12 lbs, feel incredible, skin is glowing, digestion is perfect. This program is real 🌿.
A

Andres Reyes

1 month ago
Verified

Programa definitivo de salud

Este programa de 21 dias es el definitivo para hacer un reset de salud. Los 3 productos — Colon-D, soporte hepatico y Proenzi+ — mas el plan nutricional es la combinacion perfecta. Perdi 13 libras 💪.
C

Courtney Garcia

2 months ago
Verified

Comprehensive 3-week experience

The 21-day program is a genuine commitment but the payoff is real. Lost 9 lbs and established healthy eating habits that have stayed with me for months since. Well-designed program.
J

Julio Santos

2 months ago
Verified

Tres semanas de transformacion

Tres semanas con este programa me dieron resultados que no habia logrado con nada mas. 12 libras perdidas, higado depurado, digestion perfecta y nuevos habitos de alimentacion. Completley transformado 🌟.
M

Megan Torres

2 months ago
Verified

Best detox program on the market

I've done different detox programs and this 21-day kit is the most comprehensive and effective. Lost 12 lbs, liver function improved, digestion excellent. The extended nutrition phase is what makes it special 💚.
R

Raul Espinoza

2 months ago
Verified

Perdi 14 libras sin pasar hambre

Lo que mas me gusto es que no pase hambre. El plan de nutricion te dice que comer para satisfacerte mientras el cuerpo se depura. Perdi 14 libras en 21 dias sintiendome bien todo el tiempo 🌿.
S

Sandra Rodriguez

2 months ago
Verified

My body is completely reset

After 21 days I feel like I have a completely new body. The colon is clean, the liver is regenerated, my gut is full of good bacteria. I lost 12 lbs and feel amazing 💪.
O

Oscar Vargas

2 months ago
Verified

Programa que funciona de verdad

Este no es un detox de marketing — es un programa que de verdad funciona. 3 fases bien diseñadas con ingredientes de calidad. Perdi 11 libras y mejore mi salud en todos los aspectos 💚.
P

Pamela Mitchell

2 months ago
Verified

Worth the 21-day commitment

Takes commitment but the results are real. Lost 8 lbs, digestion dramatically improved, energy levels up. The liver phase days 6-7 were the highlight. Completely recommend for anyone serious about detox.
J

Jorge Ramirez

2 months ago
Verified

Resultado que supero mis expectativas

Esperaba perder unos 5-6 libras. Perdi 13. Esperaba sentirme un poco mejor. Me siento increible. Este programa supero todas mis expectativas. La fase hepatica es la mas impactante 🌟.
B

Brittany Walker

2 months ago
Verified

Changed how I eat long-term

The nutrition guide included with the 21-day program actually changed how I eat permanently. I lost 11 lbs during the program and have kept them off for 4 months. Life-changing program ✨.
M

Miguel Delgado

2 months ago
Verified

El mas completo del mercado

Este es el programa de detox mas completo que existe. 21 dias, 3 fases, plan nutricional incluido. Perdi 13 libras y transforme mi salud digestiva completley. Lo recomiendo sin reservas 🔥.
C

Christine King

3 months ago
Verified

Second time, same great results

Did this 6 months ago and just completed it again. Same great results both times — lost 9 lbs, felt incredible by day 21. The phased approach with colon, liver and nutrition is brilliantly designed.
E

Eduardo Gomez

3 months ago
Verified

Detox que deja resultados duraderos

Lo mejor de este programa es que los resultados duran. Han pasado 3 meses desde que lo complete y sigo con 10 libras menos y una digestion perfecta. Los nuevos habitos del plan nutricional se quedaron 💚.
T

Tiffany Lewis

3 months ago
Verified

Skin glowing, energy amazing

Two weeks after completing this program my skin is the clearest it's been in years. The liver detox truly shows in your complexion. Plus I lost 10 lbs and my energy is through the roof 🌿.
C

Cesar Castro

3 months ago
Verified

21 dias que transforman

En 21 dias puede pasarle mucho a tu cuerpo si tienes el protocolo correcto. Este programa tiene ese protocolo — limpieza del colon, depuracion hepatica, probioticos y nutricion. Perdi 15 libras 💪.

Cart (0)

Your cart is empty

Continue shopping to add items